"Padmé Amidala" <gsagae@geagnhwo.com> wrote in
news:3f8d8b43$0$94881$edfadb0f@dtext02.news.tele.dk:
> Du har vel ikke tilfældigvis et link til et site, hvor jeg kan læse
> noget mere om det?
Næh, ikke som sådan, men jeg har nogle tykke bøger med gamle
opskrift-samlinger for farmaceuter.
Ellers kan man søge på National Library of Medicine på balsamum
peruvianum - det giver kun ET hit, nemlig:
[Local antiseptics in surgery--rebirth and advances]
[Article in German]
Willenegger H.
Chirurgische Klinik des Kantonsspitals Liestal/Schweiz.
The history of antisepsis is marked by names such as Pringle, Lister,
Billroth, Koch, Kocher, von Volkmann, von Nussbaum, Schloffer and
Carrel. The revolutionary initial success of Lister's method was
followed by severe setbacks because persisting biological intolerance of
the chemical and physical antiseptics prevented the main purpose of
application: killing bacteria without damaging cells. Until the
discovery of penicillin the predominantly used antiseptics were
perubalsam (balsamum peruvianum), azo-dyes (Rivanol), and sulphonamides
(Cibazol). The dawn of the "antibiotic age" demonstrated once more the
limits of locally applied therapeutic effectiveness of these substances
(antiseptics, antibiotics) and was often outweighed by the damage
caused. For the same reason systemicly applied substances frequently
lack satisfactory effectiveness in the area of tissue damage.
Experiences with intraoperative and postoperative wound lavage have
shown that favourable results achieved by this surgical procedure are
more likely due to the mechanical cleaning process than to the
effectiveness of the locally applied substances being limited by the
restricted duration of influence and the restricted depth of tissue
penetration. Taking into account earlier studies and long-term
experiences, antiseptic solutions were tested in view of their tissue
compatibility, their biologic availability, and their effectiveness in
close cooperation of clinic, bacteriology and laboratory medicine. The
coordinated investigations resulted in a solution of biguanid (Lavasept)
which is free from iodine, quicksilver, PVP and aldehyde. It can be
applied for local treatment of wounds liable to infection, as an
adjuvant for wound treatment in cases of acute tissue infections, as
well as in the surgival practise to take care of acute and chronic
infections of soft tissue. Sofar locally applied antiseptics in surgery
have proved to be less satisfactory than considered in the course of
their history due to side effects, e.g. tissue damage. Coordinated
investigations now present an antiseptic solution of biguanid which can
be used in various cases of wound treatment to prevent or counteract
infections.
Publication Types:
Review
Review, Tutorial
PMID: 8197639 [PubMed - indexed for MEDLINE]
--
Med venlig hilsen
arc@na